Dosing and Administration

Prolia is taken twice a year by subcutaneous injection1

Dosing Considerations

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Injection Infographic
Prolia packshot with syringe and card
Administration of Prolia is to only be performed by an adequately trained injector.
Please see the Product Monograph for complete dosing and administration information.
Storage and Injection

Prolia Dosing Considerations

No dose adjustment necessary in patients with renal impairment; however, adequate intake of calcium and vitamin D is important in patients with severe renal impairment or receiving dialysis. In clinical studies, patients with severe renal impairment (creatine clearance <30 mL/min) or receiving dialysis were at greater risk of developing hypocalcemia.1

Adequate intake of calcium and vitamin D is important in all Prolia patients.1

Pregnancy must be ruled out prior to administration of Prolia. Pregnancy testing should be preformed in all women of reproduction potential prior to Prolia administration. Based on findings in animals, PROLIA may cause fetal harm when administered to pregnant women.1

Pharmacodynamics of Prolia

Inhibition of bone remodeling is reversible upon discontinuation.1*

Patients treated with Prolia showed normal architecture and quality on histologic assessment and no evidence of mineralization defects, woven bone or marrow fibrosis.1

* Clinical significance has not been established.
Additional Resources
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ProVital®

Find out more about the ProVital Patient Support Program

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Multiple vertebral fractures

Find out more about multiple vertebral fractures following discontinuation of Prolia treatment MVF following Prolia discontinuation.

Discontinuation
References

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