About Prolia®

Prolia is used to treat osteoporosis (thinning and weakening of the bone) in women after menopause, who have an increased risk for fractures or cannot use other osteoporosis medicines, or for whom other osteoporosis medicines did not work well.

Prolia is also used to increase bone mass in men with osteoporosis at high risk for fracture.

learn more about Prolia®

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About Prolia®

One in four women and one in eight men have osteoporosis – and many may not even know it. Known as the “silent thief,” osteoporosis can develop without symptoms for years. It is a bone disease and is not a normal part of aging. Often, the first sign is a broken bone.
Osteoporosis Infographic

Frequently Asked Questions

Your doctor has prescribed Prolia for you. These questions and answers will provide you with important information you need to know about Prolia.

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What is Prolia?

Prolia is used to treat osteoporosis (thinning and weakening of the bone) in women after menopause, who have an increased risk for fractures or cannot use other osteoporosis medicines, or for whom other osteoporosis medicines did not work well.

Prolia is also used to increase bone mass in men with osteoporosis at high risk for fracture.

As with all prescription medications, it’s important that you take Prolia as directed by your doctor – and that you continue to take it as prescribed by your doctor.
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How does Prolia work?

Prolia works differently than other osteoporosis medications. Prolia works by blocking RANK ligand, a protein that activates the cells that break down bone. By doing this, Prolia helps increase bone mass – making your bones stronger and lowering your chance of breaking your hip, spine and nonspinal sites.
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How do I take Prolia?

Prolia is administered by a healthcare professional or trained injector. You will receive an injection given just under the skin.

Please click here for Prolia® Patient Self-Injection Instructions for Health Care Practitioners and Patients, and watch the Self-Injection Video below

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How often do I take Prolia?

Prolia is administered as a single injection under the skin every 6 months. The injection can be in your upper arm, upper thigh or abdomen. It can be given by a health professional or trained injector at any time of day, with or without food. Use the reminder card in the carton to track your upcoming Prolia injection appointment.
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What happens if I miss a dose of Prolia?

If you miss a dose you should receive your next dose as soon as convenient. Schedule your next dose 6 months from the date of your last injection.
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How will I remember to take Prolia?

ProVital is a reminder and education program that will help you start and stay on track with your Prolia treatment. As a member of the program, you will receive ongoing communications to help you learn about osteoporosis and manage your Prolia appointments. Services include:
Access to the ProVital Support Program via telephone and support to answer any questions you may have about Prolia, your drug plan coverage or monthly payment options
Newsletter series that are educational and help keep you on track with the Program.
Reminder calls one month before and after your appointment
You can also ask your doctor to give you a Prolia appointment card or ask for the reminder card with calendar stickers that come inside the box of Prolia, so you can write down the date of your next appointment.
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How long will I need to continue to take Prolia?

You should take Prolia as directed by your doctor. Your doctor may recommend you include Prolia along with calcium and vitamin D supplements. Always follow your doctor’s instructions regarding how long you may need to take Prolia.
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Who should not take Prolia?

You should not use Prolia: if you are allergic to denosumab or any other ingredient of Prolia; have low calcium levels in your blood (hypocalcemia); are less than 18 years of age; are pregnant or breast-feeding; are a woman before menopause (unless you have been diagnosed with breast cancer or are taking Prolia for the treatment or prevention of osteoporosis related to the use of corticosteroid medicines); are currently taking denosumab under the brand name XGEVA®; do not have access to a healthcare professional or trained injector.

Prolia may interfere with normal bone and tooth development in fetuses, nursing babies and children under 18 years of age. Women who are pregnant or could become pregnant should not take Prolia. Your healthcare provider should do a pregnancy test before you start treatment with Prolia. You should use an effective method of birth control (contraception) during treatment and for at least 5 months after your last dose. If you become pregnant while taking Prolia, stop taking Prolia and tell your doctor right away. Nursing mothers should not take Prolia; it may interfere with breast-feeding.

The needle cover on the single-use prefilled syringe contains dry natural rubber (latex), which should not be handled by persons allergic to it.
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What healthy lifestyle changes should I make to help manage osteoporosis?

There’s a lot you can do.

Be nutrition-wise – calcium and vitamin D are essential to bone health.

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Keep moving – strength exercises can be beneficial to your bones.

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The more you know about your condition, the better equipped you’ll be to make healthy lifestyle changes. Be proactive in making healthy lifestyle changes to help manage your osteoporosis.
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What should I tell my doctor before using Prolia?

Before you use Prolia, talk to your doctor or pharmacist if you: have low blood calcium; cannot take daily calcium and vitamin D; have had parathyroid or thyroid surgery (glands located in your neck); have been told you have trouble absorbing minerals in your stomach or intestines (malabsorption syndrome); have kidney problems or are on kidney dialysis; have ever had an allergic reaction to Prolia; plan to have dental surgery or teeth removed; have a history of cancer; are pregnant or could become pregnant.
Tell your doctor or pharmacist about all the medicines you take, including prescription and nonprescription drugs, vitamins and herbal supplements, and keep an up-to-date list of all of them.
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What are the side effects of Prolia?

Like all medications, Prolia can cause side effects, although not everybody gets them. Possible side effects include:
  • Pain, sometimes severe, in the muscles, joints, arms, legs or back
  • Low blood calcium levels (symptoms of low blood calcium may include muscle spasms, twitches, cramps, numbness or tingling in fingers, toes or around the mouth)
  • A skin condition with itching, redness and/or dryness (eczema). This was reported in 1% to 10% of patients taking Prolia. Injection-site reactions were uncommon.
  • Allergic reactions (e.g. rash, hives, or in rare cases, swelling of the face, lips, tongue, throat or trouble breathing)
  • Rash that may occur on the skin or sores in the mouth (lichenoid drug eruption)
  • Skin infection with swollen, red area of skin that feels hot and tender and may be accompanied by fever (cellulitis)
  • Common cold (runny nose or sore throat)
  • Broken bones in the spine after stopping Prolia (multiple vertebral fractures)
  • Hair loss (alopecia)

Tell your doctor right away if you have:

Fever or chills (infection)
Frequent or urgent need to urinate or burning feeling when you urinate (bladder infection)
Skin that looks red, swollen, hot or tender to touch. Infection may be accompanied by fever (cellulitis)
Severe stomach pains (pancreatitis)
Ear infection
Endocarditis (inflammation of the inner lining of the heart)†
Sore in mouth involving gums or jaw bones (osteonecrosis of the jaw)†
Allergic reaction (feeling faint, trouble breathing/wheezing, throat tightness, swelling of face, lips or tongue, rash, hives)†
Low blood calcium symptoms (muscle spasms, twitches, cramps, numbness or tingling in the fingers, toes or around the mouth)
† Stop taking drug and call your doctor or pharmacist
Alert your doctor if you have:
Any of these skin problems that do not go away or that worsen: redness; itching; rash; dry or leathery skin; open, crusted or peeling skin; blisters
New or unusual pain in your hip, groin or thigh (fracture of the thigh bone)
These are not all the possible symptoms or side effects that you may experience. It’s important to contact your doctor or pharmacist if you’re concerned about potential side effects you may be experiencing with your Prolia treatment.
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What happens if I stop taking Prolia?

After your treatment with Prolia is stopped, it is possible that broken bones in your spine may occur especially if you have a history of broken bones in the spine. Do not stop taking Prolia without first talking with your doctor. If your Prolia treatment is stopped, discuss other available treatment options with your doctor.
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What else should I consider when using Prolia?

After you start Prolia:

  • Take good care of your teeth and gums, and see your dentist regularly. If you have a history of dental problems (such as poorly fitting dentures or gum disease), see your dentist before starting Prolia. Tell your dentist that you are taking Prolia, especially if you are having dental work done.
  • A dental condition called osteonecrosis of the jaw (ONJ), which can cause tooth and jawbone loss, has been reported in patients treated with Prolia (less than 0.1%). The risk of ONJ may increase with length of time on Prolia. Tell your doctor and dentist immediately about any dental symptoms, including pain or unusual feeling in your teeth or gums, or any dental infections.
  • Some people have developed unusual fractures in their thigh bone. Contact your doctor if you experience new or unusual pain in your hip, groin or thigh.
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What should I do if I experience side effects?

If you experience side effects or if you have any concerns about side effects, contact your doctor.
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What should I do between the time I pick up my prescription at the pharmacy and my injection?

When prescribed Prolia, you will likely need to fill your prescription at a pharmacy and store Prolia in your fridge (at 2 to 8°C) in the original carton, until your injection appointment with your health professional or trained injector. Do not freeze Prolia. If removed from the refrigerator, Prolia should be kept at room temperature (up to 25°C) in the original carton and must be used within 30 days.

Protect Prolia from direct light and do not expose to temperatures above 25°C. Keep Prolia out of reach and sight of children. Do not use Prolia after the expiry date printed on the carton and label. The expiry date refers to the last day of a month.
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Patient Support Program

Sign up now for the ProVital Support Program to receive Prolia injection reminders.

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